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Strattera increases norepinephrine in the brain. Not be classified as a controlled substance, although it will be a prescription drug. Strattera works by strengthening the chemical signals between brain cells and by increasing neurotransmitters, which are brain chemicals, to improve your concentration. It may take several weeks for the full effects of Strattera to become evident. The effectiveness and safe use of Atomoxetine. Strattera increases norepinephrine in the brain.